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齊德巴坦, 齊達(dá)巴坦，齊特巴坦，WCK 5107

CAS號(hào)	1436861-97-0
規(guī)格	0.5g/包	純度	≥98%
貨號(hào)	WTM-03-00	貨期	需咨詢
品牌	河北唯特醫(yī)藥科技	庫(kù)存	20g
規(guī)格	0.5g/包
純度	≥98%
貨號(hào)	WTM-03-00
貨期	---
品牌	河北唯特醫(yī)藥科技
庫(kù)存	20g
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參考價(jià)：￥8500.00 元/包

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貨號(hào)	品牌	純度	規(guī)格	參考價(jià)	貨期
WTM-03-00	河北唯特醫(yī)藥科技	≥98%	0.5g/包	￥8500.00元/包	---

產(chǎn)品詳情

詳細(xì)信息(中文)：
齊德巴坦為新型β內(nèi)酰胺酶抑制劑。目前處于三期臨床試驗(yàn)階段。

詳細(xì)信息(英文)：
Zidebactam and WCK 5153 are novel β-lactam enhancers that are bicyclo-acyl hydrazides (BCH), derivatives of the diazabicyclooctane (DBO) scaffold, targeted for the treatment of serious infections caused by highly drug-resistant Gram-negative pathogens. In this study, we determined the penicillin-binding protein (PBP) inhibition profiles and the antimicrobial activities of zidebactam and WCK 5153 against Pseudomonas aeruginosa, including multidrug-resistant (MDR) metallo-β-lactamase (MBL)-producing high-risk clones. MIC determinations and time-kill assays were conducted for zidebactam, WCK 5153, and antipseudomonal β-lactams using wild-type PAO1, MexAB-OprM-hyperproducing (mexR), porin-deficient (oprD), and AmpC-hyperproducing (dacB) derivatives of PAO1, and MBL-expressing clinical strains ST175 (blaVIM-2) and ST111 (blaVIM-1). Furthermore, steady-state kinetics was used to assess the inhibitory potential of these compounds against the purified VIM-2 MBL. Zidebactam and WCK 5153 showed specific PBP2 inhibition and did not inhibit VIM-2 (apparent Ki [Kiapp] > 100 μM). MICs for zidebactam and WCK 5153 ranged from 2 to 32 μg/ml (amdinocillin MICs > 32 μg/ml). Time-kill assays revealed bactericidal activity of zidebactam and WCK 5153. LIVE-DEAD staining further supported the bactericidal activity of both compounds, showing spheroplast formation. Fixed concentrations (4 or 8 μg/ml) of zidebactam and WCK 5153 restored susceptibility to all of the tested β-lactams for each of the P. aeruginosa mutant strains. Likewise, antipseudomonal β-lactams (CLSI breakpoints), in combination with 4 or 8 μg/ml of zidebactam or WCK 5153, resulted in enhanced killing. Certain combinations determined full bacterial eradication, even with MDR MBL-producing high-risk clones. β-Lactam–WCK enhancer combinations represent a promising β-lactam “enhancer-based” approach to treat MDR P. aeruginosa infections, bypassing the need for MBL inhibition.

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物理化學(xué)性質(zhì)
英文名	---
中文名	---
CAS號(hào)		溶解性	---
分子量	---	熔點(diǎn)	---
密度	---	沸點(diǎn)	---

商家信息

河北唯特醫(yī)藥科技有限公司

聯(lián)系人：王經(jīng)理

號(hào)碼一： 131****

號(hào)碼二： 135****

VIP企業(yè)默認(rèn)展示聯(lián)系方式，非VIP企業(yè)僅限注冊(cè)登錄用戶可見(jiàn)

公司類(lèi)型：研發(fā)型
成立時(shí)間：2020-05-28
所在地區(qū)：河北省石家莊市
注冊(cè)資本：300萬(wàn)元

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齊德巴坦, 齊達(dá)巴坦，齊特巴坦，WCK 5107

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河北唯特醫(yī)藥科技有限公司

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齊德巴坦, 齊達(dá)巴坦，齊特巴坦，WCK 5107

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河北唯特醫(yī)藥科技有限公司

產(chǎn)品：

齊德巴坦, 齊達(dá)巴坦，齊特巴坦，WCK 5107